| Date | Opponent | Result | Record | Notes |
| 11/10/06 | Wofford | W 92-88 | 1-0 | |
| 11/17/06 | Delaware St. | W 63-43 | 2-0 | |
| 11/21/06 | Valparaiso | W 78-64 | 3-0 | |
| 11/24/06 | Gardner-Webb | W 88-76 | 4-0 | |
| 11/27/06 | Michigan | W 74-67 | 5-0 | ACC/Big 10 Challenge |
| 12/03/06 | at Virginia (25) | L 62-67 | 5-1 (0-1) | |
| 12/06/06 | at West Virginia | L 60-71 | 5-2 | |
| 12/09/06 | Savannah St. | W 74-53 | 6-2 | Reynolds Coliseum |
| 12/16/06 | Mount St. Mary's | W 80-65 | 7-2 | |
| 12/20/06 | Alabama (10) | L 75-82 | 7-3 | |
| 12/23/06 | at Cincinnati | L 71-80 | 7-4 | |
| 12/28/06 | East Carolina | W 64-57 | 8-4 | |
| 12/30/06 | UNC-Wilmington | W 72-51 | 9-4 | |
| 01/02/07 | UNC-Greensboro | W 95-93 | 10-4 | |
| 01/06/07 | Boston College | L 58-74 | 10-5 (0-2) | |
| 01/09/07 | Clemson (17) | L 76-87 | 10-6 (0-3) | |
| 01/13/07 | at Wake Forest | W 88-74 | 11-6 (1-3) | Sidney Lowe gets first ACC win, first road win |
| 01/20/07 | Duke (14) | L 56-79 | 11-7 (1-4) | |
| 01/24/07 | Virginia | L 58-71 | 11-8 (1-5) | |
| 01/31/07 | at Virginia Tech (16) | W 70-59 | 12-8 (2-5) | Sidney Lowe gets first win vs. ranked team |
| 02/03/07 | North Carolina (3) | W 83-79 | 13-8 (3-5) | Sidney Lowe gets second win vs. ranked team |
| 02/06/07 | at Georgia Tech | L 65-74 | 13-9 (3-6) | |
| 02/10/07 | at Miami | L 65-80 | 13-10 (3-7) | |
| 02/14/07 | Maryland | L 70-85 | 13-11 (3-8) | |
| 02/18/07 | Virginia Tech | W 81-56 | 14-11 (4-8) | |
| 02/21/07 | at North Carolina (4) | L 64-83 | 14-12 (4-9) | |
| 02/24/07 | at Florida State | L 52-78 | 14-13 (4-10) | Field Goals: 17—Turnovers: 19 |
| 02/28/07 | Wake Forest | W 73-66 | 15-13 (5-10) | |
| 03/03/07 | at Maryland (24) | L 59-79 | 15-14 (5-11) | |
| 03/08/07 | vs. Duke (21) | W 85-80 | 16-14 | ACC Tournament Rd. 1 |
| 03/09/07 | vs. Virginia | W 79-71 | 17-14 | ACC Quarterfinals |
| 03/10/07 | vs. Virginia Tech | W 72-64 | 18-14 | ACC Semifinals |
| 03/11/07 | vs. North Carolina (8) | L 80-89 | 18-15 | ACC Championship |
| 03/13/07 | vs. Drexel | W 63-56 | 19-15 | NIT Rd. 1 |
| 03/16/07 | vs. Marist | W 69-62 | 20-15 | NIT Rd. 2 |
| 03/20/07 | vs. West Virginia | L 66-71 | 20-16 | NIT Quarterfinals |
