| Date | Opponent | Result | Record | Notes |
| 11/17/04 | vs. New Orleans | W 92-58 | 1-0 | BCA Tournament |
| 11/18/04 | vs. Elon | W 71-45 | 2-0 | BCA Tournament |
| 11/19/04 | vs. East Carolina | W 100-66 | 3-0 | BCA Tournament |
| 11/26/04 | Campbell | W 99-44 | 4-0 | |
| 11/29/04 | Purdue | W 60-53 | 5-0 | ACC/Big 10 Challenge |
| 12/05/04 | Manhattan | W 76-60 | 6-0 | |
| 12/11/04 | Liberty | W 94-60 | 7-0 | Reynolds Coliseum |
| 12/15/04 | UL-Lafayette | W 78-72 | 8-0 | |
| 12/19/04 | at Washington (18) | L 64-68 | 8-1 | |
| 12/21/04 | at Brigham Young | W 72-61 | 9-1 | |
| 12/28/04 | vs. Columbia | W 84-74 | 10-1 | ECAC Holiday Classic |
| 12/30/04 | vs. St. John's | L 45-63 | 10-2 | ECAC Holiday Classic; Pack shoots 20% from field, including 13% (3-23) in the first half for 10 points. It's a record. |
| 01/02/05 | West Virginia | L 69-82 | 10-3 | |
| 01/09/05 | at Miami | L 66-67 | 10-4 (0-1) | |
| 01/13/05 | Duke (5) | L 74-86 | 10-5 (0-2) | |
| 01/16/05 | Georgia Tech (8) | W 76-68 | 11-5 (1-2) | Yellowjackets now 0-6 at RBC |
| 01/19/05 | at Virginia Tech | L 71-72 | 11-6 (1-3) | |
| 01/23/05 | at Maryland | W 85-69 | 12-6 (2-3) | |
| 01/26/05 | Florida St. | L 64-70 | 12-7 (2-4) | Florida St. wins first conference road game since 2001; first victory vs. Wolfpack since 1999 (ends 12-game NCSU win streak) |
| 01/29/05 | at Clemson | W 80-70 | 13-7 (3-4) | |
| 02/03/05 | at North Carolina (2) | L 71-95 | 13-8 (3-5) | |
| 02/05/05 | Virginia | L 62-64 | 13-9 (3-6) | Virginia wins for the first time at RBC |
| 02/10/05 | at Wake Forest (6) | L 75-86 | 13-10 (3-7) | Are you kidding? Free throws: NCSU, 10-12. WFU, 35-42? |
| 02/13/05 | at Georgia Tech | W 53-51 | 14-10 (4-7) | |
| 02/16/05 | Maryland (22) | W 82-63 | 15-10 (5-7) | First season sweep of Maryland since 1989. |
| 02/22/05 | North Carolina (2) | L 71-81 | 15-11 (5-8) | |
| 02/26/05 | Virginia Tech | W 74-64 | 16-11 (6-8) | |
| 03/02/05 | at Virginia | W 82-72 | 17-11 (7-8) | |
| 03/06/05 | Wake Forest (4) | L 53-55 | 17-12 (7-9) | |
| 03/10/05 | vs. Florida St. | W 70-54 | 18-12 | ACC Tournament Rd. 1 |
| 03/11/05 | vs. Wake Forest (3) | W 81-65 | 19-12 | ACC Tournament Quarterfinals |
| 03/12/05 | vs. Duke (5) | L 69-76 | 19-13 | ACC Tournament Semifinals |
| 03/18/05 | vs. Charlotte | W 75-63 | 20-13 | NCAA Tournament Rd. 1 |
| 03/20/05 | vs. Connecticut (13) | W 65-62 | 21-13 | NCAA Tournament Rd. 2 |
| 03/25/05 | vs. Wisconsin (20) | L 56-65 | 21-14 | NCAA Sweet Sixteen |
