| Date | Opponent | Result | Record | Notes |
| 11/28/50 | Furman | W 102-41 | 1-0 (1-0) | |
| 12/02/50 | Loyola-Maryland | W 71-53 | 2-0 | |
| 12/05/50 | Davidson | W 87-53 | 3-0 (2-0) | |
| 12/07/50 | at George Washington | W 86-71 | 4-0 (3-0) | |
| 12/14/50 | Eastern Kentucky | W 65-64 | 5-0 | |
| 12/16/50 | at Temple | W 83-62 | 6-0 | |
| 12/18/50 | Michigan | W 65-62 | 7-0 | |
| 12/20/50 | Villanova | L 61-68 | 7-1 | |
| 12/28/50 | Tulane | W 89-75 | 8-1 | Dixie Classic |
| 12/29/50 | Wake Forest | W 72-56 | 9-1 | Dixie Classic |
| 12/30/50 | Colgate | W 85-76 | 10-1 | Dixie Classic |
| 01/01/51 | Yale | W 85-57 | 11-1 | |
| 01/03/51 | George Washington | W 93-59 | 12-1 (4-0) | |
| 01/06/51 | at Duke | W 77-71 | 13-1 (5-0) | |
| 01/09/51 | at Davidson | W 70-61 | 14-1 (6-0) | |
| 01/12/51 | William & Mary | W 61-54 | 15-1 (7-0) | |
| 01/13/51 | at Villanova | L 64-66 | 15-2 | |
| 01/16/51 | at Wake Forest | W 64-45 | 16-2 (8-0) | |
| 01/20/51 | LaSalle | W 76-74 | 17-2 | |
| 01/23/51 | Virginia Tech | W 114-66 | 18-2 (9-0) | |
| 01/27/51 | North Carolina | W 71-58 | 19-2 (10-0) | |
| 01/31/51 | at Louisville | L 70-86 | 19-3 | |
| 02/03/51 | at William & Mary | L 78-88 | 19-4 (10-1) | |
| 02/06/51 | Temple | W 86-58 | 20-4 | |
| 02/10/51 | Duke | W 75-65 | 21-4 (11-1) | |
| 02/13/51 | Louisville | W 92-78 | 22-4 | |
| 02/17/51 | at North Carolina | W 68-53 | 23-4 (12-1) | |
| 02/20/51 | Wake Forest | W 78-56 | 24-4 (13-1) | |
| 02/24/51 | Georgetown | W 101-83 | 25-4 | |
| 03/01/51 | vs. South Carolina | W 83-53 | 26-4 | Southern Conference Tournament Rd. 1 |
| 03/02/51 | vs. Duke | W 67-63 | 27-4 | Southern Conference Semifinals |
| 03/03/51 | vs. Maryland | W 54-45 | 28-4 | Southern Conference Championship |
| 03/??/51 | vs. Conference All-Stars | W 94-70 | 29-4 | |
| 03/12/51 | vs. Seton Hall | L 59-71 | 29-5 | NIT Rd. 1 |
| 03/20/51 | vs. Villanova | W 67-62 | 30-5 | NCAA Tournament Rd. 1 |
| 03/22/51 | vs. Illinois | L 70-84 | 30-6 | NCAA Quarterfinals |
| 03/24/51 | vs. St. John's | L 59-71 | 30-7 | NCAA Consolation |
