| Date | Opponent | Result | Record | Notes |
| 12/02/49 | Washington & Lee | W 67-47 | 1-0 (1-0) | |
| 12/05/49 | Davidson | W 77-43 | 2-0 (2-0) | |
| 12/08/49 | George Washington | W 74-54 | 3-0 (3-0) | |
| 12/15/49 | Loyola-Marymount | W 62-47 | 4-0 | |
| 12/19/49 | Michigan | L 46-54 | 4-1 | |
| 12/20/49 | Michigan | W 63-52 | 5-1 | |
| 12/28/49 | Rhode Island | W 81-64 | 6-1 | Dixie Classic |
| 12/29/49 | Georgia Tech | W 57-34 | 7-1 | Dixie Classic |
| 12/30/49 | Penn St. | W 50-40 | 8-1 | Dixie Classic |
| 01/03/50 | San Francisco | W 69-54 | 9-1 | |
| 01/07/50 | at Duke | L 55-58 | 9-2 (3-1) | |
| 01/10/50 | vs. Davidson | W 44-38 | 10-2 (4-1) | Charlotte |
| 01/12/50 | William & Mary | W 72-58 | 11-2 (5-1) | |
| 01/14/50 | LaSalle | L 51-66 | 11-3 | |
| 01/17/50 | at Long Island | W 55-52 | 12-3 | |
| 01/21/50 | at North Carolina | W 61-57 | 13-3 (6-1) | |
| 01/25/50 | Louisville | W 79-53 | 14-3 | |
| 01/28/50 | Virginia Tech | W 81-56 | 15-3 (7-1) | |
| 02/02/50 | at Wake Forest | W 57-50 | 16-3 (8-1) | |
| 02/04/50 | Furman | W 74-38 | 17-3 (9-1) | |
| 02/07/50 | at William & Mary | L 50-54 | 17-4 (9-2) | |
| 02/11/50 | Wake Forest | W 73-35 | 18-4 (10-2) | |
| 02/14/50 | Duke | W 68-50 | 19-4 (11-2) | |
| 02/18/50 | at Louisville | W 66-52 | 20-4 | |
| 02/21/50 | North Carolina | W 70-44 | 21-4 (12-2) | |
| 02/25/50 | Villanova | L 64-65 | 21-5 | |
| 03/02/50 | vs. Virginia Tech | W 67-42 | 22-5 | Southern Conference Tournament Rd. 1 |
| 03/03/50 | vs. Wake Forest | W 59-53 | 23-5 | Southern Conference Semifinals |
| 03/04/50 | vs. Duke | W 67-47 | 24-5 | Southern Conference Championship |
| 03/??/50 | vs. Conference All-Stars | W 84-61 | 25-5 | |
| 03/24/50 | vs. Holy Cross | W 87-74 | 26-5 | NCAA Tournament Rd. 1 |
| 03/25/50 | vs. City College of NY | L 73-78 | 26-6 | NCAA Final Four |
| 03/28/50 | vs. Baylor | W 53-41 | 27-6 | NCAA Consolation |
