| Date | Opponent | Result | Record | Notes |
| 11/30/48 | at Hanes Hosiery | L 38-49 | 0-1 | |
| 12/03/48 | Hanes Hosiery | W 53-47 | 1-1 | |
| 12/06/48 | George Washington | W 66-37 | 2-1 (1-0) | |
| 12/10/48 | West Virginia | W 56-36 | 3-1 | |
| 12/17/48 | vs. Pittsburgh | W 77-42 | 4-1 | Durham |
| 12/20/48 | at Nevada-Reno | W 49-48 | 5-1 | |
| 12/21/48 | at Nevada-Reno | W 70-51 | 6-1 | |
| 12/23/48 | at San Francisco | L 47-54 | 6-2 | |
| 12/28/48 | vs. Wyoming | L 39-41 | 6-3 | Los Angeles Tournament |
| 12/31/48 | vs. Loyola-Marymount | L 59-61 | 6-4 | Los Angeles |
| 01/04/49 | vs. Canisius | W 76-60 | 7-4 | Cleveland |
| 01/06/49 | at Long Island | L 61-65 | 7-5 | |
| 01/08/49 | at Villanova | L59-62 | 7-6 | |
| 01/11/49 | vs. Davidson | W 64-47 | 8-6 (2-0) | Charlotte |
| 01/12/49 | Louisville | L 71-72 | 8-7 | |
| 01/15/49 | at Duke | W 53-52 | 9-7 (3-0) | |
| 01/18/49 | at Furman | W 81-57 | 10-7 (4-0) | |
| 01/22/49 | North Carolina | W 67-36 | 11-7 (5-0) | |
| 01/25/49 | Quantico | W 64-40 | 12-7 | |
| 01/28/49 | at Richmond | W 77-56 | 13-7 (6-0) | |
| 01/29/49 | at George Washington | W 60-59 | 14-7 (7-0) | |
| 02/02/49 | at Wake Forest | L 49-52 | 14-8 (7-1) | |
| 02/05/49 | William & Mary | W 66-52 | 15-8 (8-1) | |
| 02/08/49 | Wake Forest | W 82-39 | 16-8 (9-1) | |
| 02/11/49 | Duke | W 47-44 | 17-8 (10-1) | |
| 02/15/49 | Davidson | W 62-34 | 18-8 (11-1) | |
| 02/19/49 | at North Carolina | W 79-39 | 19-8 (12-1) | |
| 02/22/49 | Furman | W 76-45 | 20-8 (13-1) | |
| 02/25/49 | at Washington & Lee | W 81-46 | 21-8 (14-1) | |
| 02/26/49 | at LaSalle | W 60-56 | 22-8 | |
| 03/03/49 | vs. Wake Forest | W 64-42 | 23-8 | Southern Conference Tournament Rd. 1 |
| 03/04/49 | vs. North Carolina | W 43-40 | 24-8 | Southern Conference Semifinals |
| 03/05/49 | vs. George Washington | W 55-39 | 25-8 | Southern Conference Championship |
